INVS Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Descripción

This antibody is a rabbit polyclonal antibody raised against part of N-terminus of human INVS. The calculated molecular weight of INVS is 80 kDa, but the modified INVS protein is about 100-110 kDa.

This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.