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IL-12/IL-23 p40 Rat anti-Mouse, CoraLite 488, Clone: C17.8, Proteintech

Rat Monoclonal Antibody

Marca:  Proteintech CL488-65097-100TESTS

Detalles adicionales : Peso : 0.00010kg

Código de producto. 17284686

  • 201.00€ / 100 reacciones
Fecha estimada de envío: 17-04-2024
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Descripción

Descripción

Interleukin (IL)-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

Especificaciones

Especificaciones

IL-12/IL-23 p40
Monoclonal
5 μL/Test
Rat
Primary
Mouse
IgG2a κ
Flow Cytometry
C17.8
CoraLite 488
100 Tests
16160
Liquid
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