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STEMCELL Technologies Human Recombinant IL-12
Interleukin 12
Marca: STEMCELL Technologies 78027.1
Detalles adicionales : Peso : 0.00110kg
Descripción
- Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits
- IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ
- The IL-12 receptor is expressed on T, NK, and dendritic cells
- Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.) It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann & Rüde)
- Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.)
Especificaciones
CTL maturation factor, Cytotoxic lymphocyte maturation factor, IL-12p70, Interleukin-12, Natural killer cell stimulatory factor, NKSF | |
5 μg | |
B Cells; Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells; T Cells | |
≥95% |