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ACROBiosystems Human MAG / Siglec-4a Protein, Fc Tag

Marca:  ACROBiosystems MAG-H5254-1mg

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16477859

  • 2486.22€ / 1 miligramo
Fecha estimada de envío: 21-09-2022
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Descripción

Descripción

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81.1 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_002352.1
81.1 kDa
1 mg
Gly 20 - Pro 516
MAG,Siglec-4 A,GMA,S-MAG
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human MAG, Fc Tag (MAG-H5254) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Pro 516 (Accession # P20916-1).
-20°C
MAG / Siglec-4 A
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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Ofertas especiales

Ofertas especiales