missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Abnova™ Human JAK1 (NP_002218.2, 850 a.a. - 1154 a.a.) Partial Recombinant Protein with GST-tag expressed in baculovirus infected Sf21 cells
Used for Func, SDS-PAGE
Marca: Abnova™ P5568.5ug
Detalles adicionales : Peso : 0.02000kg
Descripción
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq]
Especificaciones
| NP_002218.2 | |
| Liquid | |
| 62kDa | |
| Baculovirus infected insect cell (Sf21) expression system | |
| Loading 1 ug protein in SDS-PAGE | |
| Store at -80°C. Aliquot to avoid repeated freezing and thawing. | |
| JAK1A/JAK1B/JTK3 | |
| JAK1 | |
| Baculovirus | |
| GST | |
| Liquid |
| Functional Study, SDS-PAGE | |
| 3716 | |
| JAK1 (Human) Recombinant Protein | |
| Glutathione sepharose chromatography | |
| 5 ug | |
| RUO | |
| JAK1 | |
| The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: JAK1 substrate peptide. ATP: 100 uM. | |
| Recombinant | |
| Baculovirus infected insect cell (Sf21) expression system | |
| 73% by SDS-PAGE/CBB staining |