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ACROBiosystems Human Fc gamma RIIIA / CD16a (V176) Protein, His Tag

SPR & BLI verified

Marca:  ACROBiosystems CD8-H52H4-50ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17186141

  • 250.91€ / 50 microgramos
Fecha estimada de envío: 14-10-2022
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Descripción

Descripción

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.7 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

Powder
>95% as determined by reduced SDS-PAGE
Human CD16a (V176), His Tag (SPR and BLI verified) (CD8-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gly 17 - Gln 208 (Accession # P08637-1).
-20°C
Fc gamma RIIIA / CD16a
His Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Fc Receptors
23.7 kDa
50 µg
Gly 17 - Gln 208
FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Unconjugated
PBS, pH7.4
HEK293
Human
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