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ACROBiosystems Human Fc gamma RIIB / CD32b Protein, HSA,His Tag

Marca:  ACROBiosystems CDB-H52S9-50ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17196201

  • 250.91€ / 50 microgramos
Fecha estimada de envío: 25-10-2022
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Descripción

Descripción

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

This protein carries a HSA tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 88.2 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Especificaciones

Especificaciones

NP_003992.3
88.2 kDa
50 µg
Ala 46 - Pro 217
FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human CD32b Protein, HSA,His Tag (CDB-H52S9) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994-1).
-20°C
Fc gamma RIIB / CD32b
HSA Tag and His Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Fc Receptors
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Ofertas especiales

Ofertas especiales