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ACROBiosystems Human ErbB3 / Her3 Protein, Fc Tag
411.28€ - 1754.00€
Especificaciones
Número de acceso | NP_001973.2 |
---|---|
Peso molecular | 94.8 kDa |
Fuente | Human ErbB3, Fc Tag (ER3-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # NP_001973.2). |
Inmunógeno | Ser 20 - Thr 643 |
Requisitos de almacenamiento | -20°C |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
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Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15896677
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ACROBiosystems
ER3-H5259-200UG |
200 μg |
411.28€
200 microgramos |
Fecha estimada de envío: 26-04-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15886677
|
ACROBiosystems
ER3-H5259-1MG |
1 mg |
1754.00€
1 miligramo |
Fecha estimada de envío: 26-04-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 94.8 kDa. The protein migrates as 116-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Especificaciones
NP_001973.2 | |
Human ErbB3, Fc Tag (ER3-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # NP_001973.2). | |
-20°C | |
ErbB3 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |
94.8 kDa | |
Ser 20 - Thr 643 | |
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |