Gibco™ Human Noggin Recombinant Protein

Descripción

Human Noggin Recombinant Protein for Western Blot, IHC, ELISA, Ctrl, FN

Noggin binds and inactivates members of the transforming growth factor-beta (TGF-β) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-β superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation.

• High purity: no interference from other proteins or contaminants
• High biological activity: more results with less protein
• Proven compatibility: Gibco proteins bioassayed with Gibco media
• High Purity Recombinant Bioactive Protein: to help ensure Gibco growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein
• High Biological Activity: in-house activity testing of Gibco Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, anti-viral, and protease assays; specific activity is determined by measuring the dose dependent inhibition of the 5ng/mL BMP-4-induced alkaline phosphatase production by ATDC-5 chondrogenic cells
• Proven Compatibility: Gibco proteins are bioassayed with Gibco media

Approved for shipment at Room Temperature or on Wet or Dry Ice.