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FRS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 12249-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16819853

  • 109.00€ / 20 microlitros

Envío estimado: 27-10-2021

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Descripción

Descripción

FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
Especificaciones

Especificaciones

FRS3
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O43559, Q52RG8, Q91WJ0
FGFR signaling adaptor SNT2, FGFR substrate 3, FRS2B, FRS2beta, FRS3, SNT 2, SNT2
Rabbit
IgG
20 μL
-20°C
Primary
107971, 10817, 316213
Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry
Unconjugated
FRS3
Liquid
Frs3
FRS3 Fusion Protein Ag2896
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
Videos
SDS
Documentos
Certificados