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FRS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 12249-1-AP-20UL
Detalles adicionales : Peso : 0.00010kg
Descripción
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.Especificaciones
FRS3 | |
Polyclonal | |
Unconjugated | |
FRS3 | |
FGFR signaling adaptor SNT2, FGFR substrate 3, FRS2B, FRS2beta, FRS3, SNT 2, SNT2 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
107971, 10817, 316213 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry | |
0.13 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O43559, Q52RG8, Q91WJ0 | |
Frs3 | |
FRS3 Fusion Protein Ag2896 | |
20 μL | |
Primary | |
Mouse, Human, Rat | |
Antibody | |
IgG |