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CLDN16 Rabbit anti-Canine, Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 27638-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815755

  • 319.00€ / 150 microlitros

Envío estimado: 22-10-2021

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Descripción

Descripción

Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle′s loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal ′handling′ of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.
Especificaciones

Especificaciones

CLDN16
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9Y5I7
claudin 16, CLDN16, HOMG3, Paracellin 1, PCLN 1, PCLN1
Rabbit
IgG
150 μL
-20°C
Primary
10686, 608218
Western Blot
Unconjugated
CLDN16
Liquid
CLDN16
CLDN16 Fusion Protein Ag26531
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Canine, Human
Videos
SDS
Documentos
Certificados