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Invitrogen™ CDK1/cyclin A2 Recombinant Human Protein

CDK1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. Recombinant full-length human CDK1 and CyclinA2 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

Marca:  Invitrogen™ PV6280

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15448933

  • 345.00€ / 10 microgramos


Fecha de envío estimada
del proveedor 02-01-2019
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Descripción

Descripción

CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Especificación

Especificación

Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
60.4/74.8kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
Human
GST Tag
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
10μg
Kinase Assay
Yes
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