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CD8a Mouse, anti-Human, PE, Clone: SK1, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60125PE
Detalles adicionales : Peso : 0.00110kg
Descripción
- The SK1 antibody reacts with CD8a, a 32 - 34 kDa type I transmembrane glycoprotein that is a subunit of CD8
- CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e.αβ) or a homodimer (αα)
- CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC class I molecules presented by an antigen-presenting cell
- It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck
- The CD8a chain binds to the α3 domain of class I MHC molecules
- CD8 is expressed by a majority of thymocytes, a subset of mature peripheral blood T cells (T cytotoxic cells), a proportion of β T cells, and at lower levels by NK cells (which predominantly express CD8a homodimers)
Especificaciones
CD8a | |
Monoclonal | |
PE | |
100 Tests | |
Human | |
T Cells, T Cells, CD8+ |
Flow Cytometry | |
SK1 | |
Mouse | |
Primary | |
IgG1 κ |