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CD59 Mouse anti-Human, FITC, Clone: MEM-43, Invitrogen™

Mouse Monoclonal Antibody

Marca:  Invitrogen MHCD5901

Detalles adicionales : Peso : 0.50000kg

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Código de producto. 10445473

  • 223.00€ / cada uno


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Descripción

Descripción

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
Especificación

Especificación

CD59, CD59
Monoclonal
FITC
CD59
Liquid
CD59
Human CD59
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
MEM-43
PBS with 4mg/mL BSA and 0.1% sodium azide
P13987
CD59, CD59 molecule complement regulatory protein, 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20
Mouse
IgG2a
0.5 mL
4° C, store in dark
Primary
966
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