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CD5 Mouse, anti-Human, APC, Clone: UCHT2, STEMCELL Technologies
Mouse Monoclonal Antibody
en la oferta
Especificaciones
Antígeno | CD5 |
---|---|
Clon | UCHT2 |
Aplicaciones | Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry |
Clasificación | Monoclonal |
Conjugado | APC |
Descripción
- The UCHT2 antibody reacts with CD5, an ∼67 kDa single-chain type I glycoprotein and member of the scavenger receptor superfamily, which is constitutively expressed on thymocytes, T cells, B cell subsets, peripheral blood dendritic cells and some leukemia and lymphoma cells, including chronic B lymphocytic leukemia (B-CLL) cells
- CD5 is expressed at low levels on thymocytes and at high density on mature T cells
- Putative ligands include CD5L and CD72
- CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T cell/B cell interactions via its physical and functional associations with the T cell receptor/CD3 complex and the B cell receptor
- Studies with CD5 knockout mice indicate that CD5 negatively regulates antigen receptor-mediated signaling in thymocytes and mature T cells
- The UCHT2 antibody binds to epitope 2 located in the extracellular domain of CD5
Especificaciones
CD5 | |
Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry | |
APC | |
Cynomolgus, Rhesus Monkey, Chimpanzee, Human | |
Primary |
UCHT2 | |
Monoclonal | |
Mouse | |
IgG1 κ |