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CD40 Mouse, anti-Human, FITC, Clone: 5C3, STEMCELL Technologies

Mouse Monoclonal Antibody

Marca:  Stemcell Technologies 60113FI.1

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17199121

  • 118.37€ / 25 tests
Fecha estimada de envío: 08-11-2022
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Descripción

Descripción

  • The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily
  • CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers
  • It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells
  • In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis
  • CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas
  • It is expressed at low levels, or not at all, on plasma cells
  • The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation
Especificaciones

Especificaciones

CD40
Monoclonal
FITC
25 Tests
Human, Chimpanzee, Rhesus Monkey, Cynomolgus, Baboon
B Cells
Functional Assay, Flow Cytometry, Immunohistochemistry
5C3
Mouse
Primary
IgG1 κ
Videos
SDS
Documentos
Certificados
Ofertas especiales

Ofertas especiales