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CD3, Super Bright 436, Clone: OKT3, Monoclonal, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 62-0037-42

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15923334

  • 253.00€ / paquete de 100


Fecha de envío estimada
del proveedor 04-04-2019
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Descripción

Descripción

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Staining Buffer (Product No. SB-4400) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Especificación

Especificación

CD3
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P07766
CD3E
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
916
Flow Cytometry
OKT3
Super Bright 436
CD3E
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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