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CD29 (Integrin beta 1) Mouse anti-Human, Super Bright 702, Clone: TS2/16, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 67-0299-42

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15933724

  • 296.00€ / paquete de 100


Fecha de envío estimada
del proveedor 25-10-2019
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Descripción

Descripción

SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No. 00-5333) for up to 3 days in the dark at 4 degrees C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 405 nm; Emission: 702 nm; Laser: Violet Laser Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company. CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
Especificaciones

Especificaciones

CD29 (Integrin beta 1)
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P05556
CD29; FNRB; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
TS2/16
Super Bright 702
ITGB1
Liquid
ITGB1
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3688
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