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CD29 (Integrin beta 1) Mouse anti-Human, Super Bright 436, Clone: TS2/16, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 62-0299-42

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15923374

  • 297.00€ / paquete de 100


Fecha estimada de envío
20-08-2020
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Descripción

Descripción

SB-4401) to minimize any non- specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company. CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
Especificaciones

Especificaciones

CD29 (Integrin beta 1)
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P05556
CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; Integrin beta-1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); very late activation protein, beta polypeptide; VLA-4 subunit beta
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
TS2/16
Super Bright 436
ITGB1
Liquid
ITGB1
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3688
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