missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD28 Syrian Hamster anti-Mouse, Clone: 37.51.1, Invitrogen™
Syrian Hamster Monoclonal Antibody
Marca: Invitrogen HM35005
Detalles adicionales : Peso : 0.02000kg
Descripción
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.Especificaciones
CD28 | |
Monoclonal | |
Unconjugated | |
Cd28 | |
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28 | |
Syrian Hamster | |
Purified | |
RUO | |
12487 | |
4° C | |
Liquid |
Flow Cytometry | |
37.51.1 | |
PBS with 0.1% sodium azide | |
P31041 | |
Cd28 | |
Mouse T lymphoma EL-4 cells. | |
2.5 mL | |
Primary | |
Mouse | |
Antibody | |
IgG |