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CD206 (MMR) Monoclonal Antibody (MR6F3), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

en la oferta

Especificaciones

Antígeno CD206 (MMR)
Clon MR6F3
Concentración 0.2 mg/mL
Aplicaciones Flow Cytometry
Clasificación Monoclonal
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Descripción

Descripción

Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. CD206 belongs to the C-type lectin family. Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. CD206 mediates phagocytic and endocytic uptake of fungal, bacterial, protozoan and viral antigens, and plays an important role in immune defense and immune regulation. A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. CD206 is considered to be one of the markers of M2 macrophages. Factors inducing its expression include: IL-4, IL-13, M-CSF, IL-6, IL-10, and glucocorticoids, while TNF-alpha, IFN-gamma, TGF-beta, and LPS have been reported to down-regulate expression of CD206. It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended.

CD206 (MMR) Monoclonal antibody specifically detects CD206 (MMR) in Mouse samples. It is validated for Flow Cytometry.
Especificaciones

Especificaciones

CD206 (MMR)
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
Mrc1
Primary
4° C, store in dark, DO NOT FREEZE!
Mrc1
MR6F3
Flow Cytometry
APC
Rat
Mouse
Q61830
17533
IgG2b κ
Affinity chromatography
Antibody
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