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CD2, Super Bright 645, Clone: RPA-2.10, Monoclonal, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 64-0029-42

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15913594

  • 283.00€ / paquete de 100


Fecha de envío estimada
del proveedor 03-05-2019
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Descripción

Descripción

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Staining Buffer (Product No. SB-4400) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 405 nm; Emission: 645 nm; Laser: Violet Laser CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction betwee CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Especificación

Especificación

CD2
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P06729
CD2
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
914
Flow Cytometry
RPA-2.10
Super Bright 645
CD2
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Baboon, Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Porcine, Rhesus Monkey
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