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CD19 Mouse anti-Human, Brilliant Ultraviolet 737, Clone: SJ25C1 (also known as SJ25-C1), BD Horizon™

Mouse Monoclonal Antibody

464.00€ - 795.00€

Especificaciones

Antígeno CD19
Clon SJ25C1 (also known as SJ25-C1)
Aplicaciones Flow Cytometry
Clasificación Monoclonal
Conjugado Brilliant Ultraviolet 737
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
17217864
Ver documentos Detalles de la promoción
BD Biosciences
612757
25 Tests
464.00€
25 tests
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Fecha estimada de envío: 23-04-2024
para ver el stock
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17207864
Ver documentos Detalles de la promoción
BD Biosciences
612756
100 Tests
795.00€
100 tests
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 15-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

The antibody was conjugated to BD Horizon™ BUV737 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye is a tandem fluorochrome of BD Horizon BUV395 with an Ex Max of 348-nm and an acceptor dye with an Em Max at 737-nm. BD Horizon Brilliant BUV737 can be excited by the ultraviolet laser (355 nm) and detected with a 740/35 filter. Due to the excitation of the acceptor dye by other laser lines, there may be significant spillover into channels detecting Alexa Fluor™ 700-like dyes (e.g., 712/20-nm filter).

Especificaciones

Especificaciones

CD19
Flow Cytometry
Brilliant Ultraviolet 737
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
SJ25C1 (also known as SJ25-C1)
Monoclonal
Mouse
Human
Human NALM1 + NALM16 cells
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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