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CD11b, Super Bright 645, Clone: ICRF44, Monoclonal, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 64-0118-41

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15923604

  • 141.00€ / paquete de 25


Fecha de envío estimada
del proveedor 29-03-2019
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Descripción

Descripción

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 405 nm; Emission: 645 nm; Laser: Violet Laser CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Especificación

Especificación

CD11b
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P11215
ITGAM
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3684
Flow Cytometry
ICRF44
Super Bright 645
ITGAM
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Baboon, Chimpanzee, Cynomolgus Monkey, Human, Rhesus Monkey
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