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CD117 (c-Kit) Rat, anti-Mouse, PE, Clone: ACK2, STEMCELL Technologies

Rat Monoclonal Antibody

Marca:  Stemcell Technologies 60034PE

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17198661

  • 547.96€ / 200 microgramos
Fecha estimada de envío: 10-11-2022
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Descripción

Descripción

  • The ACK2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
  • CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
  • Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
  • Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor
  • Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation
Especificaciones

Especificaciones

CD117 (c-Kit)
Monoclonal
PE
200 μg
Mouse
Hematopoietic Stem and Progenitor Cells
Immunofluorescence, Immunocytochemistry, Flow Cytometry, Western Blot, Immunohistochemistry
ACK2
Rat
Primary
IgG2b κ
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Ofertas especiales

Ofertas especiales