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Axl Rat anti-Mouse, Alexa Fluor® 488, Clone: MAXL8DS, eBioscience™

Rat Monoclonal Antibody

Marca:  Invitrogen 53-1084-80

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15913314

  • 118.00€ / 25 microgramos


Fecha de envío estimada
del proveedor 03-05-2019
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Descripción

Descripción

Axl is a member of the TAM receptor family, which also includes also MerTK and TYRO3. Axl contains protein kinase activity and is activated by dimerization and auto-phosphorylation upon ligand binding. In response to its ligands, Protein S and GAS6, Axl activates anti-inflammatory pathways (through SOCS-1 and SOCS-3), which limits TLR and cytokine signaling. This results in dampened inflammatory responses in macrophages and DCs. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Soluble Axl can serve as marker of liver fibrosis, cirrhosis and a number of maligcies.
Especificación

Especificación

Axl
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q00993
ARK, AZF1, UFO, Tyro7
Rat
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
26362
Flow Cytometry
MAXL8DS
Alexa Fluor® 488
Axl
Liquid
Axl
C57BL/6 mouse Axl-human IgG Fc fusion protein
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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