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Axl Rat anti-Mouse, Alexa Fluor® 488, Clone: MAXL8DS, eBioscience™

Rat Monoclonal Antibody

118.00€ - 262.00€


Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15913314 Ver documentos Invitrogen
53-1084-80
25 μg 118.00€
25 microgramos Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 22-11-2019
Añadir a la cesta
 
15923314 Ver documentos Invitrogen
53-1084-82
100 μg 262.00€
100 microgramos Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 22-11-2019
Añadir a la cesta
 
Descripción

Descripción

Axl is a member of the TAM receptor family, which also includes also MerTK and TYRO3. Axl contains protein kinase activity and is activated by dimerization and auto-phosphorylation upon ligand binding. In response to its ligands, Protein S and GAS6, Axl activates anti-inflammatory pathways (through SOCS-1 and SOCS-3), which limits TLR and cytokine signaling. This results in dampened inflammatory responses in macrophages and DCs. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Soluble Axl can serve as marker of liver fibrosis, cirrhosis and a number of maligcies.