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Arginase 1 Rat anti-Human, Mouse, PE, Clone: A1exF5, eBioscience™

Rat Monoclonal Antibody

101.00€ - 236.00€


Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15913174 Ver documentos Invitrogen
12-3697-80
25 μg 101.00€
25 microgramos Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 25-10-2019
Añadir a la cesta
 
15923174 Ver documentos Invitrogen
12-3697-82
100 μg 236.00€
100 microgramos Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 25-10-2019
Añadir a la cesta
 
Descripción

Descripción

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both, human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.