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Arginase 1 Rat anti-Human, Mouse, eFluor® 450, Clone: A1exF5, eBioscience™
Rat Monoclonal Antibody
Marca: Invitrogen 48-3697-80
Detalles adicionales : Peso : 0.01000kg
Descripción
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both, human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.Especificaciones
Arginase 1 | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
P05089, Q61176 | |
AI; ARG1; Liver Arginase; Type 1 Arginase; PGIF | |
Rat | |
IgG2a, kappa | |
25 μg | |
4° C, store in dark, DO NOT FREEZE! | |
Primary | |
11846, 383 |
Flow Cytometry | |
A1exF5 | |
eFluor™ 450 | |
ARG1 | |
Liquid | |
Arg1 | |
E.coli-derived recombit mouse Arginase 1 | |
Affinity chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Human, Mouse |