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Arginase 1 Rat anti-Human, Mouse, eFluor® 450, Clone: A1exF5, eBioscience™

Rat Monoclonal Antibody

Marca:  Invitrogen 48-3697-82

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15923304

  • 219.00€ / 100 microgramos


Fecha de envío estimada
del proveedor 27-03-2019
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Descripción

Descripción

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both, human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Especificación

Especificación

Arginase 1
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P05089, Q61176
AI; ARG1; Liver Arginase; Type 1 Arginase; PGIF
Rat
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
11846, 383
Flow Cytometry
A1exF5
eFluor® 450
ARG1
Liquid
ARG1
E.coli-derived recombit mouse Arginase 1
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse
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