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Stat1 (pY701) Mouse, Unlabeled, Clone: 4A, BD

Mouse Monoclonal Antibody

470.00€ - 595.00€

Especificaciones

Antígeno Stat1 (pY701)
Clon 4A
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15886129
Ver documentos Detalles de la promoción
BD Biosciences
612232
50 μg
470.00€
1 set
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Fecha estimada de envío: 22-04-2024
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15896129
Ver documentos Detalles de la promoción
BD Biosciences
612233
150 μg
595.00€
1 set
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 22-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).

Flow Cytometry, Immunofluorescence, Immunoprecipitation, Intracellular Staining, Western Blotting

Especificaciones

Especificaciones

Stat1 (pY701)
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a
Affinity Purified
4A
Western Blot
Unconjugated
RUO
Human, Mouse
Phosphorylated Human Stat1 Peptide
Primary
Store undiluted at -20°C.
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