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Stat1 (pY701) Mouse, Unlabeled, Clone: 14/P-STAT1, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 612133

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15826109

  • 437.60€ / 1 set


Fecha estimada de envío
03-09-2019
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Descripción

Descripción

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91kDa Stat1α and 84kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).

Flow Cytometry, Immunofluorescence, Immunoprecipitation, Intracellular Staining, Western Blotting

Especificaciones

Especificaciones

Stat1 (pY701)
14/P-STAT1
Unconjugated
Affinity Purified
Phosphorylated Human Stat1 (pY701) Peptide
150μg
Cell Biology
Primary
Human, Murine
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.