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SHC Mouse, Unlabeled, Clone: 30, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610878

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15825689

  • 333.00€ / 1 set
Fecha estimada de envío: 22-04-2024
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Descripción

Descripción

The mammalian SHC proteins, which are expressed as multiple isoforms (46, 52, and 66kDa), each contain a C-terminal SH2 domain and an N-terminal glycine/proline rich sequence. These proteins function as early signaling intermediates (also called adaptor proteins) which relay G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-induced signals via the Ras transduction pathway. To this end, the SHC proteins contain specific tyrosine residues which are phosphorylated following association with the active RTKs.
Phosphorylated SHC forms a complex with the adaptor protein GRB2. Association of the SHC-GRB2 complex with the Ras guanine nucleotide exchange factor (Ras-GEF) mediates the localization of Ras-GEF to the plasma membrane. Once at the plasma membrane, Ras-GEF activates Ras by catalyzing the Ras-GTP for Ras-GDP exchange. Over-expression of SHC results in cell transformation, and phosphorylation of SHC correlates with activation of the ERK1/ERK2 kinases. The SHC proteins are mediators of signals that are essential
for cell metabolism, growth, and differentiation.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

SHC
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human SHC aa. 359-473
50 μg
Cell Biology
Canine, Chicken, Human, Mouse, Rat
IgG1
Western Blot
30
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Sugerencias de productos

Sugerencias de productos

Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.