missing translation for 'onlineSavingsMsg'
Learn More

SHC Mouse, Unlabeled, Clone: 30, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610878

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15825689

  • 241.00€ / 1 set


Fecha estimada de envío
12-09-2019
Añadir a la cesta

Descripción

Descripción

The mammalian SHC proteins, which are expressed as multiple isoforms (46, 52, and 66kDa), each contain a C-terminal SH2 domain and an N-terminal glycine/proline rich sequence. These proteins function as early signaling intermediates (also called adaptor proteins) which relay G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-induced signals via the Ras transduction pathway. To this end, the SHC proteins contain specific tyrosine residues which are phosphorylated following association with the active RTKs.
Phosphorylated SHC forms a complex with the adaptor protein GRB2. Association of the SHC-GRB2 complex with the Ras guanine nucleotide exchange factor (Ras-GEF) mediates the localization of Ras-GEF to the plasma membrane. Once at the plasma membrane, Ras-GEF activates Ras by catalyzing the Ras-GTP for Ras-GDP exchange. Over-expression of SHC results in cell transformation, and phosphorylation of SHC correlates with activation of the ERK1/ERK2 kinases. The SHC proteins are mediators of signals that are essential
for cell metabolism, growth, and differentiation.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

SHC
30
Unconjugated
Affinity Purified
Human SHC aa. 359-473
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.