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PTP1C/SHP1 Mouse, Unlabeled, Clone: 52, BD
Mouse Monoclonal Antibody
343.00€ - 565.00€
Especificaciones
| Antígeno | PTP1C/SHP1 |
|---|---|
| Clon | 52 |
| Concentración | 250μg/mL |
| Aplicaciones | Western Blot |
| Clasificación | Monoclonal |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|
15825279
|
BD Biosciences
610125 |
50 μg |
343.00€
1 set |
Fecha estimada de envío: 17-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
|
15835279
|
BD Biosciences
610126 |
150 μg |
565.00€
1 set |
Fecha estimada de envío: 17-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.
Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PTP1C aa.. 492-597
Formula Weight [Chemical]: 68kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Especificaciones
| PTP1C/SHP1 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 52 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human PTP1C aa.. 492-597 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.