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PKBα/Akt Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

251.00€ - 434.00€

Especificaciones

Antígeno PKBα/Akt
Isotipo IgG1
Inmunógeno Human PKBα/Akt aa. 71-184
Formulación Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15815669 Ver documentos BD Biosciences
610836
50μg 251.00€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
02-12-2019
Añadir a la cesta
 
15825669 Ver documentos BD Biosciences
610837
150μg 434.00€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
02-12-2019
Añadir a la cesta
 
Descripción

Descripción

Rac (Related to the A and C kinases) protein kinase shows 73% and 68% to Protein Kinase C and PKA, respectively, and is also known as Protein Kinase B (PKB). It was also identified as the product of the v-akt oncogene from T-cell lymphomas. PKB mRNA is expressed in a wide variety of cell lines and has been detected in porcine brain, heart, liver, kidney, muscle, and ovary. Rac phosphorylates a number of physiological substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. PKB is activated in response to growth factors through the activation of PI3-kinase and Ras. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate which may induce the membrane translocation of PKB coincident with its phosphorylation and activation. Cellular stress leading to the activation of the p38 MAP kinase also induces PKB activation, indicating a multiplicity of signaling pathways that activate PKB. Upon activation, PKB associates with some members of the PKC family of kinases, such as PKCδ and PKCζ. Downstream of PKB, GSK3 is thus far the only identified substrate for PKB phosphorylated in vivo.

Immunofluorescence, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

PKBα/Akt
Human PKBα/Akt aa. 71-184
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
PKBα
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
7
250μg/mL
Store undiluted at -20°C.

For Research Use Only.