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Phospholipase Cγ1 Mouse, Unlabeled, Clone: 10/PLCGAMMA, BD

Mouse Monoclonal Antibody

241.00€ - 416.80€

Especificaciones

Antígeno Phospholipase Cγ1
Isotipo IgG1
Inmunógeno Cow PLCγ1 aa. 82 to 100
Formulación Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15815219 Ver documentos BD Biosciences
610027
50μg 241.00€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
07-10-2019
Añadir a la cesta
 
15825219 Ver documentos BD Biosciences
610028
150μg 416.80€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
07-10-2019
Añadir a la cesta
 
Descripción

Descripción

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLCγ 1, which is ubiquitously expressed, and 2) PLCγ 2, found primarily in the lymphoid system. PLCγ is essential for growth factor-induced cell motility and mitogenesis. PLCγ 1 null mice exhibit retarded embryonic growth and lethality in midgestation. Overexpression of PLCγ is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLCγ activity by growth factors is involved in cell growth and transformation.
Especificaciones

Especificaciones

Phospholipase Cγ1
Cow PLCγ1 aa. 82 to 100
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
10/PLCGAMMA
250μg/mL

For Research Use Only.