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Phospholipase Cγ1 Mouse, Unlabeled, Clone: 10/PLCGAMMA, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610028

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15825219

  • 660.00€ / 1 set
Fecha estimada de envío: 22-04-2024
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Descripción

Descripción

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLCγ 1, which is ubiquitously expressed, and 2) PLCγ 2, found primarily in the lymphoid system. PLCγ is essential for growth factor-induced cell motility and mitogenesis. PLCγ 1 null mice exhibit retarded embryonic growth and lethality in midgestation. Overexpression of PLCγ is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLCγ activity by growth factors is involved in cell growth and transformation.
Especificaciones

Especificaciones

Phospholipase Cγ1
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Cow PLCγ1 aa. 82 to 100
150 μg
Cell Biology
Canine, Chicken, Human, Mouse, Rat
IgG1
Western Blot
10/PLCGAMMA
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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For Research Use Only.