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Phospho-p21 (Thr145) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA538144

Detalles adicionales : Peso : 0.00900kg

Código de producto. 15535071

  • 451.00€ / 100 microgramos
Fecha estimada de envío: 07-05-2024
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Descripción

Descripción

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
Especificaciones

Especificaciones

Phospho-p21 (Thr145)
Polyclonal
Unconjugated
CDKN1A
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Rabbit
Antigen affinity chromatography
RUO
1026
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P38936
CDKN1A
A synthetic phosphopeptide derived from human p21Cip1 around the phosphorylation site of Thr145 (R-Q-TP-S-M)
100 μg
Primary
Human
Antibody
IgG
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