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Phospho-KCNQ3 (Thr246) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA538662

Detalles adicionales : Peso : 0.00900kg

Código de producto. 15525581

  • 473.00€ / 100 microgramos
Fecha estimada de envío: 07-05-2024
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Descripción

Descripción

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
Especificaciones

Especificaciones

Phospho-KCNQ3 (Thr246)
Polyclonal
Unconjugated
KCNQ3
BFNC, BFNC2, EBN2, Voltage-gated potassium channel subunit Kv7.3
Rabbit
Antigen affinity chromatography
RUO
110862, 29682, 3786
-20°C
Liquid
Immunohistochemistry (Paraffin)
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
O43525, Q8K3F6, O88944
KCNQ3
A synthetic phosphopeptide derived from human Kv73/KCNQ3 around the phosphorylation site of Thr246 (G-G-TP-W-K)
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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