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PHLDA1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA538941
Detalles adicionales : Peso : 0.00900kg
Descripción
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.Especificaciones
PHLDA1 | |
Polyclonal | |
Unconjugated | |
PHLDA1 | |
Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline- and glutamine-rich protein, PQ-rich protein, PQR protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, PHLDA1, PHRIP, TDAG51 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
21664, 22822, 29380 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q8WV24, Q62392, Q9QZA1 | |
PHLDA1 | |
A synthetic peptide derived from the internal region of human PHLA1 | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |