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p70 [S6K] Mouse, Unlabeled, Clone: 16, BD
Mouse Monoclonal Antibody
343.00€ - 629.00€
Especificaciones
Antígeno | p70 [S6K] |
---|---|
Clon | 16 |
Concentración | 250μg/mL |
Aplicaciones | Western Blot |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
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Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15815859
|
BD Biosciences
611260 |
50 μg |
343.00€
1 set |
Fecha estimada de envío: 16-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15825859
|
BD Biosciences
611261 |
150 μg |
Este artículo actualmente no está disponible o ha sido discontinuado. Ver la página del producto para posibles alternativas |
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Descripción
Increased protein synthesis, an obligatory step in cell proliferation, is regulated by the phosphorylation of a number of translational components, such as ribosomal protein S6. p70 S6 Kinase (p70 [S6K]), a cytosolic kinase that is primarily responsible for S6 phosphorylation, belongs to a family of at least six S6 kinases. p70 [S6K] and p85 [S6K] are two isoforms of the same kinase. Although they are encoded by the same gene, p80 [S6K] contains a 23 amino acid N-terminal extension that serves as a nuclear localization sequence. These kinases are located in a p21 ras-independent signaling pathway and are regulated by Ser/Thr phosphorylation in response to mitogenic stimulation. Activation of p70 [S6K] requires sequential phosphorylations within the autoinhibitory domain and at Thr 389. p70 [S6K] associates with PDK-1 and PKC? to form a possible PI3-K signaling complex. The immunosuppressive agent rapamycin forms an intracellular complex with FKBP12 and FRAP (RAFT1) that inhibits phosphorylation of p70 [S6K] at Thr 389 and, in turn, prevents enzyme activation. Thus, p70 [S6K] is an important regulator of cell proliferation and a potential target of agents that modify the immune and proliferative responses. p70 [S6K] has been reported to be observable migrating within a range of 60-70 kD by western blotting.
Host Species: Mouse
Clone: 16
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat p70 [S6K] aa. 2-121
Formula Weight [Chemical]: 60-70kDa
Immunofluorescence, Western Blotting
Especificaciones
p70 [S6K] | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified | |
p70 S6 Kinase |
16 | |
Western Blot | |
Unconjugated | |
RUO | |
Human, Mouse, Rat | |
Rat p70 [S6K] aa. 2-121 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.