missing translation for 'onlineSavingsMsg'
Learn More

p53 Mouse, Unlabeled, Clone: 80, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610183

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15885309

  • 308.94€ / 1 set
Fecha estimada de envío: 17-02-2023
para ver el stock

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.


Descripción

Descripción

The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene is associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20 bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase. It is thought that MDM2 is a feedback regulator of p53. In addition, a p53-inducible gene, Cip1, has been identified and shown to suppress tumor cell growth in culture.

Especificaciones

Especificaciones

p53
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
κ, IgG2a
50 μg
Cell Biology
Human, Canine
IgG2b κ
Western Blot
80
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.