P2X3 Rabbit anti-Human, Polyclonal, Invitrogen™

Descripción

PA5-30894 targets P2X3 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-30894 immunogen is recombit fragment corresponding to a region within amino acids 136 and 395 of Human P2X3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.