missing translation for 'onlineSavingsMsg'
Learn More

N-Cadherin Mouse, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610921

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15825709

  • 416.80€ / 1 set


Fecha estimada de envío
30-08-2019
Añadir a la cesta

Descripción

Descripción

Cadherins are a family of Ca2+;-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (α, β, γ). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates β-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

N-Cadherin
32
Unconjugated
Affinity Purified
Mouse N-Cadherin aa. 802-819
150μg
Cell Biology
Primary
Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.