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Munc-18 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610337

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15835409

  • 675.00€ / 1 set
Fecha estimada de envío: 22-04-2024
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Descripción

Descripción

There are two Munc-18 isoforms: Munc-18-1 and Munc-18-2. Munc-18-1 (n-sec1 or rb-sec1; 68 kDa) is a neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis. Munc-18-2 exhibits 63% amino acid sequence identity with Munc-18-1. Although Munc-18-2 is expressed in most tissues, Munc-18-1 is primarily expressed in brain. Both forms of Munc-18 bind tightly to syntaxins 1A, 2, and 3, but not to syntaxin 4. Syntaxin 1A is a plasma membrane protein implicated in synaptic vesicle docking. Following calcium entry into the presynaptic nerve terminal, the neurotransmitter-containing synaptic vesicle fuses with the plasma membrane at a region known as the active zone. Thus, by virtue of its interaction with syntaxin 1A, Munc-18-1 is thought to have an essential function in neurotransmitter release.

Especificaciones

Especificaciones

Munc-18
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150 μg
Cell Biology
Human, Mouse, Rat
IgG1
Western Blot
31
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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For Research Use Only.