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MEK5 Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

548.00€

Especificaciones

Antígeno MEK5
Clon 21
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 1
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15825729
Ver documentos Detalles de la promoción
BD Biosciences
610957
150 μg Este artículo actualmente no está disponible o ha sido discontinuado.
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Descripción

Descripción

The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: α (50kDa) and β (40kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins, indicating that MEK5α may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain to be identified.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

MEK5
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
MAP Kinase-5
21
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Human MEK5 aa. 13-188
Primary
Store undiluted at -20°C.
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For Research Use Only.