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LEDGF (Lens Epithelium-Derived Growth Factor) Mouse anti-Human, Unlabeled, Clone: 26, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 611715

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15876009

  • 647.52€ / 1 set
Fecha estimada de envío: 02-03-2023
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Descripción

Descripción

p52/p75 proteins were first identified through their interaction with transcriptional factors and splicing factors. p75 is encoded by exons 1-15 and contains 530 amino acids, while the alternatively spliced p52 is encoded by exons 1-9 and contains 333 amino acids. Both p52 and p75 have strong interactions with the VP16 activation domain and with various components of the general transcriptional machinery. p52 is the more active transcription activator and has also been shown to recruit the pre-mRNA splicing factor ASF/SF to sites of active transcription. Interestingly, p52/p75 has also been identified as Lens Epithelium-Derived Growth Factor (LEDGF). In serum free media, LEDGF stimulates the growth and survival of a variety of cells, such as lens epithelial cells, retinal photoreceptor cells, COS7 cells, skin fibroblasts, and keratinocytes. In retinal photoreceptor cells, LEDGF is found in the nucleus where it promotes resistance to serum starvation and thermal stress. Thus, the LEDGF gene encodes splice variants that may regulate gene transcription and mRNA splicing of a variety of proteins that are essential for cell growth and survival.

Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human LEDGF aa. 85-188

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

LEDGF (Lens Epithelium-Derived Growth Factor)
Monoclonal
250μg/mL
Lens Epithelium-Derived Growth Factor
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot, In vitro Assay
26
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human LEDGF aa. 85-188
150 μg
Cell Biology
Human
IgG1
Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales

For Research Use Only.