JNK1 with control Mouse anti-Human, Unlabeled, Clone: G151-333, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 551196
Detalles adicionales : Peso : 0.02000kg
C-Jun NH2-terminal kinase (JNK1) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73. Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK1 kinase activity establishes it as a proline-directed kinase related to the MAP kinases and cyclin dependent kinases. JNK1 migrates with an apparent molecular weight of 46 kDa by SDS-PAGE. A related protein of 55 kDa has similar kinase activity. JNK1 may act as a tumor promoter in response to UV-irradiation since its activity is potently stimulated by such radiation. This has relevance to the observations that c-Jun transcriptional activity is upregulated by UV irradiation. The G151-333 antibody recognizes both the 46 kDa JNK1 and a related ∽55 kDa protein (which may be a modified form of JNK1). It does not cross-react with JNK2. G151-333 precipitates an active kinase. A bacterially expressed fusion protein of human JNK1 was used as immunogen.
|JNK1 with control|
|Purified Mouse Anti-Human JNK1 (50μg); HeLa Control Lysate (50μg)|
|Store undiluted at -20°C.|
For Research Use Only.