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JAK1 Mouse, Unlabeled, Clone: 73, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610231

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15825349

  • 241.00€ / 1 set


Fecha estimada de envío
06-09-2019
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Descripción

Descripción

The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-α and IFN-γ. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-α or IFN-γ. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-α and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-α or IFN-γ, respectively.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

JAK1
73
Unconjugated
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Canine, Chicken, Frog, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2b, κ
RUO
Store undiluted at -20°C.
Monoclonal
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For Research Use Only.