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Ezrin Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610602

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15825539

  • 333.00€ / 1 set
Fecha estimada de envío: 23-04-2024
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Descripción

Descripción

First described as an 80kDa protein concentrated in the apical cytoskeletal region of intestinal brush border cells, ezrin is now recognized as a major substrate of protein tyrosine kinases, such as the epidermal growth factor (EGF) tyrosine kinase. Ezrin is expressed at high levels in intestine, kidney, and placenta. In placenta, ezrin is present as monomers and non-covalent oligomers in tight association with actin microfilaments. In the human epidermoid carcinoma cell line A431, microvilli-like structures appear within 30 seconds after the addition of EGF. These structures give way to membrane ruffles after 2-5 minutes, followed by cell rounding after 10-20 minutes. At the same time, ezrin is recruited into these structures and oligomers are formed following its tyrosine phosphorylation. It is thought that tyrosine phosphorylation triggers the formation of ezrin oligomers.

Especificaciones

Especificaciones

Ezrin
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50 μg
Cell Biology
Canine, Human
IgG1
Western Blot
18
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Sugerencias de productos

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Ofertas especiales

Ofertas especiales

For Research Use Only.